Treatment-resistant depression (TRD) is common condition in that have not benefitted from conventional treatments like medications, therapy, and other modalities of intervention. Depression is a multi-factorial disorder, however, some patients do not respond to conventional treatments due to medication resistance, lack of efficacy and tolerance issues. Research has shown that TRD treated with ketamine has been successful and effective. This has resulted in patients relying on medication based treatment less and benefitting more from therapy and lifestyle modifications. Ketamine and therapy is, again, often the best result for having relief from TRD. Many find after just one treatment, they are feeling better and more hopeful.